Understanding Lexapro: How Long Does Lexapro Take to Work?

Updated March 10, 2025

Authored By:

Joe Gilmore

Edited By

Amy Leifeste

Medically Reviewed By

Javier Rodriguez-Winter

Authored By:

Joe Gilmore

Edited By

Amy Leifeste

Medically Reviewed By

Javier Rodriguez-Winter

Understanding Lexapro: How Long Does Lexapro Take to Work?

Lexapro, also known by the drug name escitalopram, is a commonly prescribed antidepressant that is frequently used to manage symptoms of both anxiety and depression [1]. Understanding how and when Lexapro begins to work can be essential for those starting the medication, as patience and consistent use are key. 

Many people who start Lexapro have similar questions: How Long Does It Take Lexapro to Work for Anxiety? How do I know Lexapro is working? How long does it take to adjust to Lexapro? This article will cover these highlights as it explores how Lexapro works, its effects, common FAQs, and how it compares with similar medications. 

What Is Lexapro?

Lexapro is a selective serotonin reuptake inhibitor (SSRI). SSRIs inhibit serotonin reuptake, allowing more availability of this chemical in the brain. Serotonin is a neurotransmitter involved in regulating mood, emotions, and sleep. 

Lexapro is often prescribed for individuals with generalized anxiety disorder (GAD) and major depressive disorder (MDD) because its effect on boosting serotonin levels is essential for managing these conditions effectively.Unlike medications that have a sedative effect or work immediately, Lexapro requires a few weeks of use before most people notice a meaningful change.

The benefits of Lexapro are not limited to its anxiety or depression relief but also to its relatively low risk of significant side effects compared to older classes of antidepressants. It’s considered a first-line treatment for anxiety and depression because it tends to be well-tolerated and effective for many people. 

How Does Lexapro Work?

Lexapro works by preventing the reuptake, or reabsorption, of serotonin into brain cells [2]. By increasing serotonin levels in the brain, it helps stabilize mood and reduce symptoms of anxiety or depression. The brain relies on serotonin to help regulate mood, so increasing its availability can lead to a more balanced emotional state over time.

For many people, Lexapro’s effects are not immediately noticeable because the medication gradually adjusts underlying brain chemistry. Adjusting serotonin levels typically takes several weeks, which is why patience and consistent use are critical.

Can Lexapro Work Immediately?

A common question for new users is, “Can Lexapro work in a week?”.

The short answer is (most likely) no. While some medications can bring immediate relief, Lexapro is not fast-acting. Instead, it gradually builds up in the system and changes serotonin levels over several weeks.

While most individuals will not feel immediate relief, some may experience mild effects in the first week, such as slight drowsiness or a calming effect. However, these feelings are often subtle and do not reflect the full therapeutic effect of the medication.

How Fast Does Lexapro Work for Anxiety?

So, how long does it take for Lexapro to work for anxiety? If you’re taking Lexapro for anxiety, initial effects may start to show within 1-2 weeks [1], but it often takes up to 6 weeks for full therapeutic effects to become evident [2]. 

How long Lexapro takes to work for anxiety can vary widely depending on individual factors like metabolism, body chemistry, and the severity of symptoms. Dosage also plays a role, as doctors may begin with a lower dose to minimize initial side effects and then increase as needed for the optimal therapeutic dose.

While Lexapro is not a quick fix, it is highly effective once it reaches therapeutic levels in the bloodstream. It’s important to pair medications with other forms of anxiety and depression management, like counseling, therapy, and healthy lifestyle choices. 

How Long Does It Take Lexapro To Work?

The question of how long does it take Lexapro to start working is common. Most people notice significant improvements within 4-6 weeks, although some might start feeling better sooner. Lexapro’s full impact is not instant but builds over time as serotonin levels adjust.

Knowing that it may take a few weeks for Lexapro’s full effect to start working can help manage expectations and encourage consistent use. Skipping doses or stopping too soon can disrupt the process, so it’s important to follow your prescription closely.

What Will I Feel When I Start Lexapro?

When first starting Lexapro, mild side effects like nausea, dry mouth, fatigue, or even a bit of insomnia are common. Some people describe feeling “off” or “weird” in the first few days as their body adjusts. These initial side effects are generally temporary and tend to lessen within a week or two as the body adapts [3].

From a mental health stance, patients have reported feeling a slight sense of detachment or emotional dulling at first, which can be unsettling. These feelings are often part of the adjustment period and do not represent the final outcome of the treatment.

How Do I Know If The Lexapro Is Working?

Determining whether Lexapro is working involves monitoring for signs of improved mood, reduced anxiety, decreased depressive episodes, and a better overall sense of well-being. For example, daily tasks may become easier to manage, work motivation may increase, and feelings of dread or sadness might feel less overwhelming. 

Progress can be subtle and take several weeks, so keeping a journal of symptoms or changes in mood can help you track improvements accurately. Additionally, others close to you, such as family members or close friends, may notice changes, even if they seem subtle to you. Asking for their feedback may provide a helpful insight into your experience on Lexapro. 

SSRIs: How Do They Compare?

While Lexapro is highly effective for many, comparing it with other SSRIs can offer a broader perspective on treatment options.

Lexapro vs. Zoloft

Lexapro and Zoloft (drug name: sertraline) are both SSRIs but differ slightly in their effects. Lexapro is often preferred for treating anxiety disorders, while Zoloft has broader FDA approval for conditions like obsessive-compulsive disorder (OCD). Both medications take 4-6 weeks to show full effects, but individual responses can vary [5].

Lexapro vs. Prozac

Prozac (fluoxetine) has a longer half-life of 6-7 days [4] compared to Lexapro’s half-life of 1-2 days (27-33 hours) [1]. Prozac’s longer half-life means it stays in the bloodstream longer, which can impact its side effects and withdrawal experience. Prozac is also a stimulant, so it may be more suitable for people who experience lethargy or fatigue. Like Lexapro, Prozac takes a few weeks to start working, but it can feel more energizing, which some people may prefer.

Lexapro vs. Celexa

Celexa (citalopram) is closely related to Lexapro and often seen as less potent. Both medications require several weeks to work, but Lexapro is generally considered to have fewer side effects. Celexa may work slightly differently, so some people may find they respond better to one than the other.

Lexapro vs. Effexor

Effexor (venlafaxine) is technically an SNRI (serotonin-norepinephrine reuptake inhibitor), meaning it affects both serotonin and norepinephrine levels [6]. Effexor may work faster for some individuals, particularly those with significant anxiety, but it can also cause withdrawal symptoms if stopped abruptly.

How Long Does It Take for Lexapro to Work for Depression?

For those taking Lexapro to treat depression, 4-8 weeks is the typical time frame for the medication to reach its full effect. This period may vary based on symptom severity, individual metabolism, and other health considerations. Some people may notice minor improvements within the first two weeks, such as increased energy or motivation, but significant relief from depressive symptoms takes time.

What Are Lexapro’s Immediate Effects? How Does Lexapro Make You Feel the First Week?

During the two weeks of taking Lexapro, common side effects include drowsiness, nausea, and possibly an initial increase in anxiety [1]. These sensations are normal and usually resolve as the body adapts to the medication. Some people report a slight mood lift, but it is typically mild and does not represent Lexapro’s full therapeutic potential.

When Is the Best Time to Take Lexapro for Anxiety?

The best time to take Lexapro depends on individual preferences and any side effects experienced. If Lexapro causes drowsiness, it may be more comfortable to take it at night. [7] But if Lexapro causes sleep disturbances for you, taking it in the morning may be more appropriate. Consult your healthcare provider to decide the best time based on your lifestyle and how your body responds to the medication.

How Do You Know If Lexapro Is Working?

Assessing whether or not Lexapro is working involves looking for symptom relief and improvements in overall mental well-being. Signs of Lexapro working may include better sleep, reduced anxiety, and a more stable mood. These indicators suggest that the medication is taking effect, although it’s essential to be patient and give Lexapro enough time to work.

Are there any other ways to know if Lexapro is working besides waiting for symptoms to subside?

Observing changes in daily activities, focus, and reduced negative thoughts can also indicate Lexapro’s effectiveness. Improvements in behavior, such as fewer conflicts or increased desire to engage in activities, may reflect the medication’s positive impact on overall mood and functioning.

Can You Drink Alcohol on Lexapro?

While drinking alcohol on Lexapro is generally not recommended, some individuals may consume it in moderation. Alcohol can interfere with Lexapro’s effectiveness and worsen side effects like drowsiness or dizziness. Discuss your alcohol consumption habits with your doctor to understand potential risks and determine if drinking while taking Lexapro is safe for you.

Lexapro FAQs

Can Lexapro help with anxiety immediately?

Lexapro does not have fast-acting relief for anxiety or depression symptoms, and most people start to see small improvements within 1-2 weeks, with full effects often taking 4-6 weeks.

What does it feel like when Lexapro starts working?

When Lexapro starts working, individuals may notice gradual relief in anxiety or depressive symptoms. Life and work may feel more manageable and emotions more balanced, though changes are usually subtle at first. 

What is the success rate of Lexapro for anxiety?

Lexapro has shown effectiveness for anxiety disorders, with success rates around 67% [8]. Individual response can vary depending on factors like dosage, genetics, and adherence to treatment.

Does Lexapro make you feel weird at first?

Yes, some people feel “weird” initially, experiencing symptoms like mild nausea, dizziness, or emotional detachment. These side effects usually subside as the body adjusts.

Is 10mg Lexapro enough for anxiety?

The standard starting dose of Lexapro for generalized anxiety disorder (GAD) is 10mg per day and generally does not exceed this amount. For major depressive disorder (MMD), the initial dose is also 10mg but may be increased to 20mg per day if necessary [1]. Dosage adjustments may be needed based on individual responses, so it’s essential to consult your doctor before adjusting your medication. 

What mg of Lexapro works best for anxiety?

The typical dose for anxiety is 10-20mg, with some starting lower to minimize side effects [1]. The ideal dose varies, and doctors may increase it gradually based on response.

How long does Lexapro take to kick in daily?

Lexapro begins to kick in after about 1-2 weeks of taking the medication daily. However, for some people, it can take up to 4-6 weeks. Daily effects are subtle and are not felt in the first few weeks.

Get Evidence-Based Treatment for Mental Health Conditions at Connections

Anxiety and Depression Disorder can severely impact your well-being, limiting your full potential and enjoyment of life. However, supportive counseling, effective therapies, and medication (as needed) can help you recover and regain your sense of purpose and joy. 

If you or a loved one are struggling with mental health illnesses like anxiety or depression – treatment is available at Connections. Our staff provides compassionate and knowledgeable care with customized treatment plans. 

Our friendly facilities offer a variety of treatments, including:

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Sources

  1. https://www.ncbi.nlm.nih.gov/books/NBK557734/
  2. https://www.ncbi.nlm.nih.gov/books/NBK554406/
  3. https://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825
  4. https://www.mayoclinicproceedings.org/article/S0025-6196(11)65005-2/fulltext#:~:text=After%20prolonged%20use%2C%20SSRIs%20should,to%20treat%20SSRI%20withdrawal%20symptoms.
  5. https://my.clevelandclinic.org/health/drugs/20089-sertraline-tablets
  6. https://www.mayoclinic.org/drugs-supplements/venlafaxine-oral-route/description/drg-20067379
  7. https://www.mayoclinic.org/drugs-supplements/escitalopram-oral-route/description/drg-20063707
  8. https://pmc.ncbi.nlm.nih.gov/articles/PMC4054541/
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